Advanced pandemic preparedness and response through high-quality data and AI

AURORAI strengthens EU’s capacity to act swiftly and effectively against future pandemics, including unknown pathogens (Disease X), by harnessing AI and high-quality, trustworthy data. The project develops a unified platform of explainable, ethical, and fast-learning AI tools that address the key barriers to pandemic resilience: fragmented data, limited forecasting ability, weak early-warning systems, and complex decision-making under uncertainty. AURORAI delivers five main innovations. First, a Decentralised Knowledge Graph (DKG) will serve as EU’s trusted, FAIR-compliant data backbone, enabling secure, interoperable, and bias-aware cross-border data use while preserving sovereignty. Second, the Multi-Pathogen Disease X (MP-DX) Modelling Tool will provide rapidly adaptable, explainable models of disease dynamics, grounded in a One Health approach and enhanced by transfer learning for emerging threats. Third, the Early Warning and Outbreaks Prediction (EW-OP) Tool will combine demographic, behavioural, and mobility data to deliver in-time forecasts, “what-if” scenarios, and evaluation of pharmaceutical and non-pharmaceutical countermeasures. Fourth, an AI-agent based Decision Support System (DSS) will integrate heterogeneous data, expert knowledge, and causal reasoning into multi-criteria analyses, supporting proportionate and evidence-based interventions. Finally, a Knowledge Hub (KH) will ensure co-creation with healthcare professionals, policymakers, and citizens, enhancing transparency, trust, and uptake. By embedding social sciences and humanities expertise, AURORAI guarantees societal relevance, ethical compliance, and fairness in AI-driven preparedness. Validated across four use cases and levels (EU, national, and local), AURORAI will empower decision-makers with actionable intelligence, reduce the burden of future pandemics, and strengthen Europe’s health resilience.