Smart and MultiFunctional 3D printable prO-Regenerative biologiCal matrix modulating

Current chronic wound (CW) management is insufficient and fails to provide reliable skin regeneration. The EU-funded FORCE REPAIR project will develop a multifunctional wound dressing for a pro-regenerative environment and mechanical stability during CW treatment. The project will employ state-of-the-art technologies to create 3D-printed biological scaffolds tailored to patients’ needs. Antibacterial bio-adhesive ink in combination with polypeptides promoting innervation and vascularisation, as well as Wharton Gel Complex will boost extracellular matrix proteins. The UV-treated dressing will contract the wound to help its closure. The 3D-printed dressing will be tested in vitro with human exudate and validated in vivo on animal CW or bacterial infection models. Regulatory and stakeholder feedback will guide product development to its translation to clinical settings.