A Comparative Study of Classi fier Ensembles for Karyotyping

Authors: Iñigo Barandiaran and Grégory Maclair and Izaro Goienetxea and Carlos Jauquicoa and Manuel Graña

Date: 12.09.2012


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Abstract

The karyotyping step is essential in the genetic diagnosis process, since it allows the genetician to see and interpret patient's chromosomes. Today, this step of karyotyping is a time-cost procedure, especially the part that consists in segmenting and classifying the chromosomes by pairs. This paper presents a compartive study of image classi cation of banded human chromosomes for automated karyotyping (AKS), by using classi er ensembles. The goal of this contribution is to propose and evaluate a solution to automate the karyotyping, from microscope images to the obtention of the classi ed chromosomes. For this purpose, we have evaluated several approaches based on classi er ensembles trying to nd a solution that shows better trade-o between accuracy and computational cost.

BIB_text

@Article {
author = {Iñigo Barandiaran and Grégory Maclair and Izaro Goienetxea and Carlos Jauquicoa and Manuel Graña},
title = {A Comparative Study of Classi fier Ensembles for Karyotyping},
pages = {1400-1407},
volume = {243},
keywds = {

Karyotyping, classi er ensembles, Pattern Recognition


}
abstract = {

The karyotyping step is essential in the genetic diagnosis process, since it allows the genetician to see and interpret patient's chromosomes. Today, this step of karyotyping is a time-cost procedure, especially the part that consists in segmenting and classifying the chromosomes by pairs. This paper presents a compartive study of image classi cation of banded human chromosomes for automated karyotyping (AKS), by using classi er ensembles. The goal of this contribution is to propose and evaluate a solution to automate the karyotyping, from microscope images to the obtention of the classi ed chromosomes. For this purpose, we have evaluated several approaches based on classi er ensembles trying to nd a solution that shows better trade-o between accuracy and computational cost.


}
isbn = {978-1-61499-104-5},
isi = {1},
date = {2012-09-12},
year = {2012},
}
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